cochlea hair cell restoration

Cochlear Architecture Critical Part of Hair Cell Regeneration

The ability to restore hearing by regenerating outer hair cells in the cochlea of the inner ear, sometimes referred to as biological solutions for hearing loss, has shown success in restoring hearing sensitivity in animal studies. New research, however, indicates that restoring hearing is more than regenerating lost or damaged outer hair cells. In a…

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acousia therapeutics hearing loss drug

Acousia Therapeutics Receives €10 Million Investment to Advance Pipeline of Preclinical Hearing Loss Drug Candidates

TÜBINGEN, GERMANY — Acousia Therapeutics, a privately held biotech firm developing novel therapies for inner ear disease and pathologies, announced this week the closing of a €10 million (approximately $11.8M USD) Series B financing round to “advance its pipeline of preclinical drug candidates into clinical stage”.  According to the announcement, the financing round was led…

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hearing loss restoration rna injection

Scientists Regenerate Cochlear Hair Cells in Guinea Pigs Using RNA Injection

The cochlear hair cells of humans and other mammals–unlike some animal species (like birds for example)–cannot be restored after damage. Recent research has indicated, however, that manipulation of signaling pathways could lead to hair cell regeneration. Using a sustained-release formulation of small interfering RNAs (siRNAs) delivered via nanoparticles into the cochlea of noise-injured guinea pigs,…

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akouos genetic hearing loss restore

Boston-Based Biotech, Akouos, Nets $7.5M Investment to “Restore and Preserve Hearing”

BOSTON, MASSACHUSETTS — Biotechnology startup, Akouos, announced that it has raised $7.5 million in seed funding. The company, which was spun out of the Harvard Innovation Labs, is developing novel therapies and delivery systems to prevent hearing loss and restore hearing in genetically defined populations. New Enterprise Associates (NEA), who led the seed funding along…

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stem cells cochlear inner ear

Study Shows Potential Promise and Peril in Reversing Cochlear Hearing Loss

Hearing loss is a serious global morbidity that affects 360 million people worldwide, according to the World Health Organization. At a basic level, hearing loss of adult onset can be a source of social isolation and even depression for individuals coping with its ill-effects. Even more consequential, children with hearing loss are at risk of…

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stem cell inner ear grow

New Study Shows Inner Ear Tissue Can be Grown from Human Stem Cells

In a study published on-line May 1, 2017, researchers at Indiana University School of Medicine announced they have successfully developed a method to grow inner ear tissue from human stem cells—a finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders. The study, published…

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cochlear hair cell anatomy

Researchers Discover Molecular Mechanism for Stabilizing Inner Ear Hair Cells

LEXINGTON, KENTUCKY — University of Kentucky (UK) researchers have discovered a molecular mechanism required for stabilizing stereocilia, the sensory “hair cells” housed within the inner ear. The discovery provides new insights into the workings of stereocilia and this new understanding could enhance further exploration of new therapies to treat or prevent damage to the fragile…

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hair cell regeneration cochlea

Clonal Expansion Leads to Hair Cell Regeneration

According to the World Health Organization over 5% of the world’s population has some degree of hearing loss. Inner ear hair cell and auditory nerve damage, typically caused by noise exposure, ototoxic drugs, viral or bacterial infection, and aging accounts for more than 80% of all cases of hearing loss. Regeneration of these damaged hair…

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hair cell regeneration deaf

Hair Cell Regeneration to Improve Hearing Remains Promising

Even though so-called disruptive technology, e.g, over-the-counter hearing aids, has been a big focus of the National Academy of Sciences recommendations to changes in hearing health care, other more futuristic innovations may hold sway in the treatment of hearing loss. Hair cell regeneration is one of these potential breakthroughs, and it is the cover story…

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Researchers regenerate hair cells in deafened mice and improve their hearing

By David H. Kirkwood BOSTON—When scientists finally discover a cure for sensorineural hearing loss, the key that unlocks the door for them will probably be some mechanism to stimulate the regeneration of sensory hair cells in the human cochlea. The toll that age, noise, ototoxic medicines, and infections take on these hair cells is the…

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