decibel therapeutics hearing loss treatment

Decibel Therapeutics Raises $82M to Advance Gene Therapies to Restore Hearing and Balance

BOSTON, MASSACHUSSETTS – Decibel Therapeutics, a clinical-stage biotechnology company developing novel restorative gene therapeutics to treat hearing loss and balance disorders, today announced the closing of an oversubscribed Series D financing, which raised $82.2M.

The financing was led by OrbiMed, with new investments from BlackRock Health Sciences, Casdin Capital, Janus Henderson, Samsara BioCapital and Surveyor Capital (a Citadel company). Existing investors also participated in the financing, including Foresite Capital, GV, S-Cubed Capital, Sobrato Capital, SR One, Third Rock Ventures and other institutional investors. In conjunction with the financing, the company has appointed Peter A. Thompson, M.D., F.A.C.P., a partner at OrbiMed, to its board of directors.

 

Advancing Gene Therapy Program for Hearing Loss

 

Proceeds will be used in part to support clinical and preclinical studies needed to advance Decibel’s therapeutic pipeline. DB-OTO, Decibel’s investigational gene therapy to restore hearing in children with congenital deafness due to a deficiency in the otoferlin gene, is in preclinical studies, and Decibel expects to initiate clinical testing in 2022.

The program, developed in collaboration with Regeneron Pharmaceuticals, uses a proprietary, cell-selective promoter to precisely control gene expression in cochlear hair cells. DB-020, Decibel’s investigational drug candidate to prevent the ototoxicity associated with cisplatin-based chemotherapy, is in a phase 1B study in cancer patients, with initial human efficacy data expected in 2021.

“Hearing and balance disorders have historically been overlooked by the biopharma industry, even though they exact a devastating toll on the lives of hundreds of millions of people around the globe. At Decibel, we are dedicated to restoring hearing and balance with precision therapeutics designed to deliver the right genetic medicine specifically to the right cells in the ear. We are grateful to this group of outstanding investors for choosing to partner with us to advance this vision.”

–Laurence Reid, Ph.D., Chief Executive Officer of Decibel

“We believe Decibel has built an outstanding team and is developing a pipeline of important new medicines to treat conditions of the inner ear,” said Peter Thompson, M.D., partner at OrbiMed. “OrbiMed is very pleased to support Decibel as they advance their pipeline and build a leading company in this important and emerging field.”

 

About Decibel Therapeutics

Decibel Therapeutics is a clinical-stage biotechnology company focused on developing treatments that restore functional hair cells within the inner ear to treat disorders of hearing and balance. Leveraging industry-leading single-cell genomics capabilities and proprietary gene therapy technologies, Decibel has established the world’s first comprehensive research, discovery and drug development platform aimed at restoring hearing and balance function. Decibel’s pipeline, including its lead gene therapy program (DB-OTO) to treat congenital monogenic deafness and its ototoxicity prevention program, is designed to deliver on our vision of a world in which the privileges of hearing and balance are available to all. 

 

Source: Decibel Therapeutics


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