Indiana University Cancer Center Researcher Receives $5.7M Grant to Study Chemo-Induced Hearing Loss, Toxicities

INDIANAPOLIS, INDIANA —A researcher at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center has been awarded a five-year, $5.7 million National Cancer Institute grant to evaluate long-term health outcomes for cancer patients who receive platinum-based chemotherapies.  An internationally recognized expert on cancer survivorship, Lois B. Travis, MD, ScD, leads the ongoing study that could lessen…

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hearing loss prevention chemotherapy fennec

Development of Ototoxicity Drug, PEDMARK™, Faces Setback Following FDA Response

RESEARCH TRIANGLE PARK, NORTH CAROLINA — Fennec Pharmaceuticals Inc., a specialty pharmaceutical company, announced that it received a Complete Response Letter (CRL) on August 10, 2020 from the U.S. Food and Drug Administration (FDA) regarding its New Drug Application for PEDMARK™ (a unique formulation of sodium thiosulfate), for intravenous administration for the prevention of ototoxicity…

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hearing loss prevention chemotherapy fennec

Fennec Announces FDA Filing Acceptance and Priority Review for Ototoxicity Drug, PEDMARK

RESEARCH TRIANGLE PARK, NORTH CAROLINA – Fennec Pharmaceuticals Inc., a specialty pharmaceutical company, announced that the U.S. Food and Drug Administration (FDA) has accepted for filing and granted Priority Review for the company’s New Drug Application (NDA) for PEDMARK™ (a unique formulation of sodium thiosulfate). PEDMARK is an investigational drug for the prevention of ototoxicity…

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decibel therapeutics hearing loss prevention

Decibel Therapeutics Publishes Encouraging Results from Phase 1a Clinical Trial of DB-020

BOSTON, MASSACHUSSETTS — Decibel Therapeutics, a development-stage biotechnology company developing novel regenerative therapeutics for hearing loss and balance disorders, announced that Phase 1a trial results demonstrating the safety and tolerability of its lead candidate, DB-020, have been published in the peer-reviewed journal Investigational New Drugs. DB-020 is being developed for the prevention of cisplatin-induced hearing…

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chemo hearing loss tinnitus outcomes

Symptoms of Hearing Loss and Tinnitus May Indicate Poor Outcomes in Cancer Survivors

Development of chemotherapy-induced neuropathy (CIN), hearing loss, and/or tinnitus, in cancer survivors may be predictive of increased risk of severe symptom burdens and reduced quality of life (QoL), according to a study published in the European Journal of Oncology Nursing. All three conditions, CIN, hearing loss and tinnitus significantly detracts from patient QoL in numerous…

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hearing loss cisplatin drug sens-401

Study finds Sensorion’s Investigative Drug Prevented Cisplatin-Induced Hearing Loss By More Than 50 Percent

MONTPELLIER, FRANCE — French biotech firm, Sensorion, announced the upcoming publication this week in the Journal of Otology & Neurotology of a new study showing oral clinical-stage SENS-401 (the company’s investigative drug) significantly prevented cisplatin-induced hearing loss in preclinical models. Cisplatin, a commonly-used chemotherapy agent to treat various forms of cancer, causes significant levels of…

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hearing loss cancer chemo

Study: Sodium Thiosulfate Treatment Significantly Reduces Chemotherapy-Induced Hearing Loss in Children

LOS ANGELES, CALIFORNIA — According to a new study, investigators at the Children’s Hospital Los Angeles and 37 other Children’s Oncology Group hospitals in the U.S. and Canada have found that sodium thiosulfate helps prevent cisplatin-induced hearing loss in children with cancer. Results of the randomized, controlled, phase 3 study, were published in this month’s…

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Study suggests that sound therapy may help protect ears against cancer drugs

ROCKVILLE, MD—Next to being exposed to excessive noise, one of the most common causes of irreversible hearing loss in people of all ages is exposure to chemotherapy for the treatment of cancer. Cisplatin and the aminoglycoside antibiotics, two classes of drugs commonly used with cancer patients, are both toxic to mechanosensory hair cells, the receptor…

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