NIH Genomics Researchers Identify Unique Set of Proteins that Restore Hearing in Zebrafish

WASHINGTON, D.C. — National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study, led by investigators at the National Human Genome Research Institute (NHGRI), may inform the development of treatments for hearing loss in humans. The findings were published in Cell Genomics.…

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inner ear

USC Scientists Identify Natural Barrier to Regeneration of Inner Ear Sensory Cells

LOS ANGELES, CALIFORNIA — Scientists from the University of Southern California (USC) Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. Overcoming this barrier may be a first step in returning inner ear cells to a newborn-like…

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fx-322 hearing loss treatment

Frequency Therapeutics Announces Publication of Phase 1/2 Data of FX-322 in Acquired Sensorineural Hearing Loss

WOBURN, MASSACHUSSETTS – Frequency Therapeutics, Inc. (Nasdaq: FREQ), a clinical stage biotechnology company focused on harnessing the body’s innate biology to repair or reverse damage caused by a broad range of degenerative diseases, today announced the publication of its FX-322 Phase 1/2 study results in Otology & Neurotology, a leading peer reviewed journal focused on…

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inner ear cochlea hair cells

Researchers Discover Inner Ear Development in Embryos is Similar to Crystal Formation

An interdisciplinary study headed by Professor David Sprinzak, a researcher from the School of Neurobiology, Biochemistry and Biophysics at the George S. Wise Faculty of Life Sciences at Tel Aviv University, showed for the first time that physical forces are involved in the development of the inner ear in mammalian embryos. “We identified a new developmental…

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hair cell regeneration johns hopkins

Researchers Find Molecular ‘Switch’ Controls Ability to Repair Hearing Loss in Mice

In a study in mice, Johns Hopkins Medicine researchers have found a molecular ”switch” that turns off the animal’s ability to repair damaged cells in the inner ear. The findings shed light on regenerative abilities that are present in many species of birds and fish, but get turned off in mammals, including humans. The study…

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Researchers Identify Role of Crucial Protein in Development of New Inner Ear Hair Cells

BALTIMORE, MARYLAND — Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. These hair cells are vital for hearing. Some of these cells amplify sounds that come into the ear, and others transform sound…

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pipeline therapeutics hearing loss treatment pipe-505

Pipeline Therapeutics Initiates Phase 1/2a Clinical Trial of PIPE-505 to Treat Sensorineural Hearing Loss

SAN DIEGO, CALIFORNIA –Pipeline Therapeutics, a biopharmaceutical company focused on the development and commercialization of first-in-class small molecules for neuroregeneration, today announced the initiation of a Phase 1/2a trial of the company’s lead product candidate, PIPE-505, a small molecule gamma secretase inhibitor (GSI), in sensorineural hearing loss (SNHL) associated with hearing speech in noisy environments.…

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inner ear stem cell research

USC Stem Cell Researchers Find Simpler Way to Make Inner Ear Hair Cells

LOS ANGELES, CALIFORNIA — Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida have found a simpler way to generate the sensory cells of the inner ear. Their approach uses direct reprogramming to produce sensory cells known as “hair cells,” due to their hair-like protrusions that sense sound waves.  The study was published this…

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decibel therapeutics hearing loss

Decibel Therapeutics Appoints New CEO; Announces Strategic Research Focus on Regenerative Medicine for Inner Ear

BOSTON, MASSACHUSSETTS — Biotech startup, Decibel Therapeutics, announced today that the company has appointed Laurence Reid, Ph.D., as acting chief executive officer, bringing extensive experience in biotech company building. According to the company announcement, CEO Steven Holtzman is retiring and will become a strategic business advisor to the company. As CEO, Dr. Reid brings experience in…

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hair cell regeneration research ohsu

New Research on Cochlear Hair Cell Development May Offer Clues for Future Hearing Loss Treatment

PORTLAND, OREGON — New research reveals a key insight into the development of cochlear hair cell bundles, found within the inner ear. Hair bundles are precisely arranged cellular structures deep within the spiral cavity of the inner ear. Together, they convert vibrational energy into electrical signals in the brain that translate into the sensation of…

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