Researchers Identify Role of Crucial Protein in Development of New Inner Ear Hair Cells

BALTIMORE, MARYLAND — Researchers at the University of Maryland School of Medicine (UMSOM) have conducted a study that has determined the role that a critical protein plays in the development of hair cells. These hair cells are vital for hearing. Some of these cells amplify sounds that come into the ear, and others transform sound…

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pipeline therapeutics hearing loss treatment

Pipeline Therapeutics Initiates Phase 1/2a Clinical Trial of PIPE-505 to Treat Sensorineural Hearing Loss

SAN DIEGO, CALIFORNIA –Pipeline Therapeutics, a biopharmaceutical company focused on the development and commercialization of first-in-class small molecules for neuroregeneration, today announced the initiation of a Phase 1/2a trial of the company’s lead product candidate, PIPE-505, a small molecule gamma secretase inhibitor (GSI), in sensorineural hearing loss (SNHL) associated with hearing speech in noisy environments.…

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inner ear stem cell research

USC Stem Cell Researchers Find Simpler Way to Make Inner Ear Hair Cells

LOS ANGELES, CALIFORNIA — Scientists from the USC Stem Cell laboratories of Neil Segil and Justin Ichida have found a simpler way to generate the sensory cells of the inner ear. Their approach uses direct reprogramming to produce sensory cells known as “hair cells,” due to their hair-like protrusions that sense sound waves.  The study was published this…

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decibel therapeutics hearing loss

Decibel Therapeutics Appoints New CEO; Announces Strategic Research Focus on Regenerative Medicine for Inner Ear

BOSTON, MASSACHUSSETTS — Biotech startup, Decibel Therapeutics, announced today that the company has appointed Laurence Reid, Ph.D., as acting chief executive officer, bringing extensive experience in biotech company building. According to the company announcement, CEO Steven Holtzman is retiring and will become a strategic business advisor to the company. As CEO, Dr. Reid brings experience in…

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hair cell regeneration research ohsu

New Research on Cochlear Hair Cell Development May Offer Clues for Future Hearing Loss Treatment

PORTLAND, OREGON — New research reveals a key insight into the development of cochlear hair cell bundles, found within the inner ear. Hair bundles are precisely arranged cellular structures deep within the spiral cavity of the inner ear. Together, they convert vibrational energy into electrical signals in the brain that translate into the sensation of…

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inner ear hair cells

Reprogramming Inner Ear to Regrow Lost Hair Cells? New Discovery Holds Promise for Future Hearing Loss Treatments

BOSTON, MASSACHUSETTS — A new discovery from a team led by Massachusetts Eye and Ear researchers may bring scientists a step closer to developing treatments that regrow the missing cells that cause hearing loss. In a new study, published online December 4, 2019, in Nature Communications, scientists report a new strategy to induce cell division in the…

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hair cell regeneration hearing loss therapy

Researchers Find Proteins That May Hold Key to Restoring Inner Ear Hair Cells

BALTIMORE, MARYLAND —  Researchers at Johns Hopkins Medicine, report that they have identified a pair of proteins that precisely control when hair cells (sound detecting cells) are born in the mammalian inner ear. The proteins, described in a report published June 12 in eLife, may hold a key to future therapies to restore hearing in…

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frequency therapeutics financing development fx-322

Frequency Therapeutics Raises $62 Million in Latest Financing Round to Support Hearing Loss Drug Development

WOBURN, MASSACHUSSETTS — Frequency Therapeutics, a clinical-stage biotechnology company focused on harnessing the body’s innate biology to repair or reverse damage caused by a broad range of degenerative diseases, today announced the closing of a $62.0 million Series C financing. Frequency will use the proceeds to support the clinical development of FX-322, a regenerative therapeutic…

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New Trial Raising Hope for Development of First Drug to Restore Hearing

LONDON, UNITED KINGDOM — Researchers at UCLH’s Royal National Throat Nose and Ear Hospital (RNTNEH) and UCL Ear Institute are leading a drug trial aimed at regenerating the sensory receptors (hair cells) in the inner ear. While long thought to be irreversible, past animal studies have indicated that these cells can be regenerated through the…

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