Sound Pharmaceuticals Advances Phase 2 Clinical Trial in Cystic Fibrosis Patients to Prevent Hearing Loss
SEATTLE, WASHINGTON AND CHARLESTON, SOUTH CAROLINA — Sound Pharmaceuticals, a Seattle-based biotech firm, announced that first-patient-in has been achieved in the STOP Ototoxicity Phase 2 clinical trial. This novel interventional study with the company’s oral drug, SPI-1005, is aimed to prevent and treat ototoxicity in patients with Cystic Fibrosis undergoing intravenous (IV) tobramycin for the…
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Decibel Therapeutics and Cocoon Biotech Announce Research Collaboration
BOSTON, MASSACHUSETTS — Biotech startup, Decibel Therapeutics, has announced a research collaboration with Cocoon Biotech to apply Cocoon’s proprietary silk fibroin platform to the development of therapeutics for hearing and balance disorders. According to the announcement, the companies will jointly conduct research into drug formulations optimized for transtympanic delivery to the ear, and Decibel will…
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Spiral Therapuetics Receives $3.7M Investment to Advance Treatment of Hearing Loss and Inner Ear Disorders
SAN FRANCISCO, CALIFORNIA — According to a news report out this week, early-stage pharmaceutical company Spiral Therapeutics has received a $3.7 million investment towards the development of treatments for hearing loss and other inner ear related disorders. The Series A funding round was led by Camden Partners Nexus, a biomedical-focused venture fund, and Savoir Capital. Spiral Therapeutics’ initial…
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Frequency Therapeutics Completes Enrollment in Safety Trial for Hearing Restoration Drug Candidate, FX-322
WOBURN, MASSACHUSSETTS – Biotech startup, Frequency Therapeutics, announced this week the completion of enrollment in the single dose safety trial to evaluate FX-322, the company’s leading drug candidate for hearing restoration. The randomized, double-blind, placebo-controlled trial will be assessing the safety of a single dose of FX-322 given by intratympanic administration in adult patients with…
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Decibel Therapeutics Obtains Exclusive License to Develop and Commercialize ORC-13661 from Oricula Therapeutics
BOSTON & SEATTLE — Boston-based biotech firm, Decibel Therapeutics, announced this week that it has obtained “an exclusive, worldwide license to the development and commercialization of ORC-13661” from Oricula Therapeutics for the prevention of hearing loss and balance disorders due to the use of aminoglycoside antibiotics. As part of the agreement with Decibel, Oricula will…
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Auris Medical Receives FDA Guidance for Investigative Drug to Treat Sudden Sensorineural Hearing Loss
ZUG, SWITZERLAND — Biopharmaceutical company Auris Medical Holdings announced today that it has received feedback from a Type C meeting with the U.S. Food and Drug Administration (FDA) related to the development plan and regulatory pathway for AM-111, the company’s investigational treatment for sudden sensorineural hearing loss. The meeting had been conducted at the request of…
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Sensorion to Begin Patient Enrollment for Safety Study of Vertigo Drug, Seliforant
MONTPELLIER, FRANCE — Biotech firm Sensorion announced the initiation of patient enrollment in a Phase 2a study (SENS-111-202) to confirm the absence of certain side effects commonly experienced with meclizine (specifically, anticholinergic side effects like sedation and memory loss) during an evoked vestibular imbalance. SENS-111-202 is a randomized, double-blind, double-dummy, placebo-controlled, cross-over trial in patients designed…
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Frequency Therapeutics Launches US Clinical Trials of Hearing Loss Drug; Akouos Raises $50M for Gene Therapy R&D
Biotech startup, Frequency Therapeutics, announced today that the first patients have been treated in a Phase 1/2 clinical trial to evaluate the company’s investigative compound FX-322, the company’s lead Progenitor Cell Activation (PCA) candidate for hearing restoration. The randomized, double-blind, placebo-controlled trial will assess the safety of FX-322 given by intratympanic administration in adult patients…
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Decibel Therapeutics Snags $55 Million Series C Financing for Hearing Drug Development
BOSTON, MASSACHUSETTS — Biotech startup, Decibel Therapeutics, announced that it has raised $55M in a Series C financing round. According to the announcement, all the existing investors–Third rock Ventures, GV, SR One and Regeneron Pharmaceuticals–participated in the financing round and were joined alongside new investors: Foresite Capital, Bessemer Trust, Schroder Adveq, SCubed Capital, Longevity, and…
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Frequency Therapeutics Receives $2M Grant to Investigate Hearing Restoration for US Military
Biotech startup, Frequency Therapeutics, announced today that it has received a U.S. Department of Defense (DoD) Hearing and Balance Research Award grant. The $2 million dollar, peer-reviewed grant will be used to investigate the company’s unique Progenitor Cell Activation (PCA) approach to hearing restoration for military personnel with service-related hearing loss. Prevention of hearing loss…
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