TAMPA, FLORIDA — The first ever medication to treat age-related hearing loss could potentially receive FDA approval through a comprehensive study being conducted at the University of South Florida.
Robert Frisina, PhD, chair of the USF Medical Engineering Department and director of the USF Global Center for Hearing and Speech Research, and his team were awarded a U.S. patent for his theory that you can slow hearing loss by combining supplements for the hormone aldosterone with anti-inflammatory medications, such as aspirin or ibuprofen.
“Our novel idea, embodied in the new patent, involves boosting aldosterone to young adult levels, to make the ear ‘young’ again.”
–Robert Frisina, PhD
Aldosterone is a naturally-occurring steroid that influences sodium and potassium regulation in the body, including the inner ear used for hearing. Its level typically decreases as we age, impacting auditory perception.
Making the Ear ‘Young Again’
The research is part of a five-year, $9 million grant awarded from the National Institutes of Health to USF’s Global Center.
Robert Frisina, PhD, chair of the USF Medical Engineering Department and director of the University of South Florida Global Center for Hearing and Speech Research.
Since its renewal launch in 2016, the study has included pre-clinical trials on mice. The aging mice received subcutaneous, time release aldosterone treatments for 4 months, equivalent to about 7-8 years of treatment for people. Frisina and his colleagues found untreated aging mice experienced a 50 percent decline in aldosterone compared to young adult mice. However, following treatment, the levels rose to a near normal range.
It’s important to note that the hormone supplement did not induce potential negative side effects, such as elevating blood pressure. Most importantly, the treated mice did not undergo age-related hearing loss during the study, whereas the control mice did suffer from continued age-linked hearing impairment.
Frisina’s team is now in the process of licensing the patent and if successful, will then conduct four levels of FDA human clinical trials in collaboration with the pharmaceutical company doing the licensing.
Once the drug is FDA-approved, it would then be available to the public. Its eventual commercialization could be life-changing for many, as age-related hearing loss is the number one communication disorder of our elderly population, and impacts more people than any other neurodegenerative disease of aging.
Source: USF
Lets talk frank, honest and truthfully:
The reason why hearing loss is progressive is due to:
1. Continued amplification damage due to complete lack of knowledge of hearing aid CI implant settings required by the 8th nerve for its functions. WE actually need only 30-50% of the actual power required to correct hearing loss, and cognitive degradation. But don’t tell that to these uneducated hearing aid manufacturers.
WE need to change their mindset on this!!!!!!!!!
Based on this finding, There is no such animal like age related hearing loss. After the initial damage is done and there is evidence of hearing loss, we need to apply corrective amplification before the thresholds drop below 20 db HL. If we can accomplish this there may be no further deterioration in the thresholds.
My reduced settings are helping people hear better and helping with cognitive tasks. The rate of progression has definitely slowed down!
Do you have any research articles to back up these claims?